Aikace-aikacen Ma'aikatan Antithrombotic Bakwai
Akwai nau'ikan sunadaran guda biyu tare da tasirin antithrombotic a cikin dafin maciji, ɗayan yana iya samun Enzyme mai alaƙa da fibrinolytic enzyme ana kiransa fibrinolytic enzyme (plasmine, FLE). hydrolysis na sauran abubuwan coagulation da platelet membrane, tare da bayyanannen tasirin antithrombotic.Sauran shine ta hanyar hana shirye-shiryen Prothrombin yana kunna don jinkirta tsarin coagulation, kuma ba shi da aikin enzyme.
Irin wannan nau'in enzyme da Atoda et al ne ya fara samar da shi kuma ya tattauna tsarin maganin rigakafi na furotin na anticoagulant, An tabbatar da cewa tasirin coagulation factor IX ko coagulation factor X akan calcium ion Forming 1: 1 hadaddun don tsawanta lokacin coagulation;Daga baya, Lu et al.daga Agkistrodon acutus a kudancin Anhui An keɓe wani abu na maganin ɗigon jini ACFI daga dafin maciji.Liu Qing Liang et al.An gano cewa ACFI na dauke da sinadarin calcium ion, an kuma tabbatar da cewa aikinta na maganin jijiyar jini da tsarin sararin samaniya yana da alaka da ion calcium. Daga baya, Xu Xiaolong da sauransu sun raba dafin Agkistrodon acutus daga Agkistrodon acutus ta hanyar ingantacciyar hanyar rabuwa Wani nau'in maganin hana jini ACFI I Binciken aiwatar da tsarin ya gano cewa yana kama da AC FI kuma yana cikin rukuni na biyu.Zhai Ning et al.ware wani ne na maganin jijiyar jini daga dafin Agkistrodon acutus, kuma an yi nazarin abubuwan da ke tattare da shi na zahiri da na sinadarai, kuma an gano cewa ba shi da wani aiki na fibrinolytic kuma ba shi da phospholipase A 2 aiki da aikin zubar jini.Qian Xiaojiang da sauransu sun raba dafin Agkistrodon acutus daga Hunan.An raba Lei Danqing ta hanyoyi uku na chromatography Kuma aikin plasmin ya inganta sosai.Saboda bangaren plasmin yana dauke da bangaren zubar jini yana da wuya a rabu, kuma darajar aikace-aikacensa na asibiti ba a bayyane yake ba.Li Zhaoyan et al Ta ƙoƙarce-ƙoƙarce don samun fibrinolytic enzyme ba tare da abubuwan zubar jini ana ba da tallafin fasaha ta hanyar.Zhou Xianli [18] ya tabbatar ta hanyar gwaje-gwaje cewa Thrombin kamar enzyme da plasmin daga Agkistrodon halys venom suna da tasirin thrombolytic a fili, amma tasirin plasmin kai tsaye ya fi na thrombin kamar enzyme, don haka, thrombin kamar enzyme shine jinkirin thrombolytic wakili, wanda. yana sa sake dawo da jijiyoyin jini a hankali, Haɓaka juriya na jijiyoyin jini a cikin yankin ischemic, da tsira daga fashewar jijiyoyin jini da ke haifar da zubar jini Cleavage yana da tasiri mai kyau a farkon matakin thrombosis, kuma ana amfani da su tare, Yana iya ragewa. da sashi da kuma cimma sakamako na anticoagulant da thrombolytic.Aikace-aikace na Bakwai Antithrombotic Agents Akwai nau'o'in sunadaran da ke da tasirin antithrombotic a cikin dafin maciji, daya yana iya samun Enzyme da ke hade da fibrinolytic enzyme ana kiransa fibrinolytic enzyme (plasmine, FLE). Fibrin mai lalata da fibrinogen, Babu kunna plasminogen a cikin jikin mutum, babu hydrolysis na sauran abubuwan coagulation da membrane platelet, tare da tabbataccen tasirin antithrombotic.Sauran shine ta hanyar hana shirye-shiryen Prothrombin yana kunna don jinkirta tsarin coagulation, kuma ba shi da aikin enzyme.
Irin wannan nau'in enzyme da Atoda et al ne ya fara samar da shi kuma ya tattauna tsarin maganin rigakafi na furotin na anticoagulant, An tabbatar da cewa tasirin coagulation factor IX ko coagulation factor X akan calcium ion Forming 1: 1 hadaddun don tsawanta lokacin coagulation;Daga baya, Lu et al.daga Agkistrodon acutus a kudancin Anhui An keɓe wani abu na maganin ɗigon jini ACFI daga dafin maciji.Liu Qing Liang et al.An gano cewa ACF ya ƙunshi calcium ion An kuma tabbatar da cewa aikinta na maganin jijiyar jini da tsarin sararin samaniya yana da alaƙa da ions calcium.Daga baya, Xu Xiaolong da sauransu sun ware dafin Agkistrodon acutus daga Agkistrodon acutus ta hanyar ingantacciyar hanyar rabuwa.Zhai Ning et al.keɓe wani sabon abu na anticoagulant daga dafin Agkistrodon acutus, kuma an yi nazarin abubuwan da ke tattare da shi na zahiri da na sinadarai, kuma an gano cewa ba shi da aikin fibrinolytic kuma ba shi da phospholipase A 2 aiki da aikin zubar jini.Qian Xiaojiang da sauransu sun raba dafin Agkistrodon acutus daga Hunan.An raba Lei Danqing ta hanyoyi uku na chromatography Kuma aikin plasmin ya inganta sosai.Saboda bangaren plasmin yana dauke da bangaren zubar jini yana da wuya a rabu, kuma darajar aikace-aikacensa na asibiti ba a bayyane yake ba.Li Zhaoyan et al Ta ƙoƙarce-ƙoƙarce don samun fibrinolytic enzyme ba tare da abubuwan zubar jini ana ba da tallafin fasaha ta hanyar.Zhou Xianli [18] ya tabbatar ta hanyar gwaje-gwaje cewa Thrombin kamar enzyme da plasmin daga Agkistrodon halys venom suna da tasirin thrombolytic a fili, amma tasirin plasmin kai tsaye ya fi na thrombin kamar enzyme, don haka, thrombin kamar enzyme shine jinkirin thrombolytic wakili, wanda. yana sa sake dawo da jijiyoyin jini a hankali, Haɓaka juriya na jijiyoyin jini a cikin yankin ischemic, da tsira daga fashewar jijiyoyin jini da ke haifar da zubar jini Cleavage yana da tasiri mai kyau a farkon matakin thrombosis, kuma ana amfani da su tare tare.
Yana iya rage sashi kuma cimma sakamako na anticoagulant da thrombolytic.
Lokacin aikawa: Oktoba-19-2022