Inhibitory na antitumor bangaren I na Agkistrodon halys venom akan yaduwar cutar kansar huhu na mutum A549

[Abstract] Manufar: Don nazarin tasirin Agkistrodon acutus venom tumor suppressor bangaren I (AAVC-I) akan hana yaduwa da apoptosis na ciwon huhu na mutum A549 Kwayoyin.Hanyoyi: Hanyoyin hanawa na AAVC-I a cikin nau'i daban-daban akan kwayoyin A549 don 24h da 48h an auna su ta hanyar MTT;HE tabo da kuma Hoechst 33258 fluorescence tabo an yi amfani da su don lura da apoptosis daga ilimin halittar jiki;An gano furcin furotin bax ta hanyar immunohistochemistry.Sakamako: MTT ya nuna cewa AAVC-I na iya hana yaduwar kwayoyin A549 a cikin lokaci-lokaci da kuma dogara da kashi;Bayan jiyya na AAVCI na sa'o'i 24, an lura da pyknosis na nukiliya, hyperchromatic na nukiliya da jikin apoptotic a karkashin microscope;Immunohistochemistry ya nuna cewa matsakaicin ƙarancin gani ya karu tare da karuwar ƙwayar ƙwayoyi, yana nuna cewa furcin furotin bax ya kasance daidai da tsari.Kammalawa: Bangaren Antitumor I na Agkistrodon acutus venom na iya hana cutar daji ta huhu na mutum A549 kuma ya haifar da apoptosis, wanda zai iya kasancewa yana da alaƙa da ƙayyadaddun ƙa'idodin bayyanar bax.