Pharmacokinetics na thrombin daga Agkistrodon acutus a cikin berayen

Haemocoagulase Acutus (Halase), sabon thermostatic a cikin ci gaban halase, babban aiki ne na thrombobin kamar enzyme (TLE) wanda aka samo daga dafin maciji na Agkistrodon acutus Don nazarin magunguna na Halase, hanyar rediyoisotope mai lamba 125Ⅰ da radiyo tare da TCA. An yi amfani da precip-itate a cikin berayen.Sakamako ya nuna cewa ƙimar AUC tana da alaƙa da inganci tare da allurai a ƙarƙashin hanyoyin da aka yi amfani da su duka, kuma ma'aunin daidaitawa shine 0.999 8 da 0.999 0 bi da bi;Matsalolin miyagun ƙwayoyi a cikin hanta, saifa da zuciya ya kai kololuwar bayan mintuna 5 na gudanarwa yayin da yawancin sauran gabobin suka isa cikin minti 30, sannan a hankali suna raguwa;a kowane lokaci, ƙaddamar da ƙwayoyi a cikin hanta ya kasance mafi girma fiye da na sauran kyallen takarda;An fitar da Halase gaba daya kuma galibi a cikin fitsari.% Thrombin daga Agkistrodon acutus wani nau'in thrombin ne wanda aka ware kuma an tsarkake shi daga dafin Agkistrodon acutus.Wani sabon nau'in maganin hemostatic ne wanda ƙungiyarmu ta haɓaka Pharmacokinetics na thrombin daga Agkistrodon acutus a cikin berayen an yi nazarin ta hanyar 125 I-labeled radioisotope da hazo trichloroacetic acid hade da gano rediyoaktif.Sakamakon ya nuna cewa ƙimar AUC da aka auna ta hanyoyi guda biyu an haɗa su da kyau tare da kashi, kuma ma'auni na daidaitawa sun kasance 0.9998 da 0.9990, bi da bi;Abubuwan da ke cikin miyagun ƙwayoyi a cikin hanta, splin da zuciya shine mafi girman 5 min bayan gudanarwa, yayin da a yawancin sauran kyallen takarda shine mafi girman 30 min bayan gudanarwa, sannan a hankali ya ragu;A kowane lokaci, abun ciki na miyagun ƙwayoyi a cikin hanta yana da mahimmanci fiye da na sauran kyallen takarda;Bugu da kari, fitar da thrombin na Agkistrodon acutus ya cika, galibi ta fitsari