Dafin Maciji Daga Agkistrodon (Macijin Mataki Biyar) Ya Kamata Ayi Magani Da Hoton Maganin Maganin Magani

Dafin Maciji Daga Agkistrodon (Macijin Mataki Biyar) Ya Kamata Ayi Magani Da Maganin Maganin Cutar

Takaitaccen Bayani:

An gudanar da gwaje-gwaje na asibiti guda biyu, gwajin gwajin da aka yi amfani da shi na wuribo da kuma gwajin gwaji mai inganci.Dukkanin raunukan suna zubar da jini ta hanyar yankan bangon ciki a tiyatar ciki.Babban alamun warkewa sune asarar jini, lokacin hemostasis da asarar jini a kowane yanki.Randomized placebo a cikin gwaje-gwajen asibiti a cikin lokuta 180 na ɗan adam: rabon daidaitattun maki zuwa placebo, 2 u da 3 u ƙungiyoyi uku, preoperative 15-20 mintuna guda ɗaya na jijiya, sakamakon yana ba da shawarar wannan allurai biyu a cikin zub da jini, lokacin zub da jini da asarar jini a kowace juzu'in yanki ya fi placebo, amma babu alaƙa-amsa martani tsakanin ƙungiyoyi biyu.A cikin gwajin kulawa mai kyau, akwai marasa lafiya 324 a cikin rukunin gwaji da marasa lafiya 108 a cikin ƙungiyar kulawa, kuma an ba da kashi ɗaya na 2U a cikin rukunin gwaji na 15-20 mintuna kafin tiyata ta hanyar allura guda ɗaya.Ba a ga wani mummunan halayen ba a cikin gwaje-gwajen da ke sama.

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Nazarin ya nuna cewa waɗannan macizai masu dafin sun fi haifar da guba masu rarraba jini da neurotoxins, waɗanda ke haifar da yaduwar jini na jini (DIC) da zubar jini na gaba, girgiza da gazawar gabbai da yawa.Dangane da tsarin binciken da aka yi na maganin guba na jini na dafin maciji a kudancin Anhui, an gano DIC a matsayin daya daga cikin halayen da ke tattare da raunin maciji tare da guba da wuri, wanda ya bambanta da maganganun gargajiya na DIC.Saboda haka, an gabatar da manufar "DIC like" ciwo a cikin majinyata masu cizon maciji a karon farko a kasar Sin (1988).An gano cewa TLE da FE sune manyan abubuwan da suka haifar da wannan "DIC like" (1992).Wannan yana da matukar mahimmanci don bayyana halaye na canje-canjen jini a cikin marasa lafiya da dafin maciji mai matakai biyar, kuma yana ba da tushen ka'idar aikace-aikacen takamaiman maganin rigakafi don magance wannan rikitarwa.

A binciken da aka yi kan tsarin zubar jini da dafin maciji mai mataki biyar ke haifarwa, an kuma gano cewa wannan dafin maciji yana da tasiri a kan sassa uku na tsarin jinin jini (coagulation factor, platelets da bangon jijiyar jini), daga cikinsu akwai zubar jini. toxin kai tsaye yana rinjayar permeability na capillaries.A lokaci guda kuma, an gano cewa zubar da jini mai tsanani da kumburin gaɓoɓin gaɓoɓin da suka ji rauni ba su da sauƙi a warware su, waɗanda ke da alaƙa da toshewar samar da jini na thoracic duct lymphatic coagulation factor da rashin saurin gudu na lymphatic.A cikin dogon lokaci tare da Cibiyar Snakebite na Qimen, waɗannan asali na asali da kuma sakamakon bincike na asali sun taka muhimmiyar rawa wajen tsara tsarin kula da maciji da kuma tabbatar da lafiyar macijin maciji, kuma sun sami gagarumin tasiri na zamantakewa.Nasarar binciken sun sami lambar yabo ta Kimiyya da Fasaha ta Lardin Anhui, Kyautar Ci gaban Kimiyya da Fasaha na Lardin Anhui (1993), Ma'aikatar Lafiya (A) Kyautar Rukunin Nasarar Kimiyya da Fasaha (1991);A shekarar 1989, kamfanin ya yi hadin gwiwa da Cibiyar Kayayyakin Halittar Halitta ta Wuhan, don samar da rigakafin kwayar cutar dafin penta na maciji, wanda shi ne nasara ta farko a kasar Sin.A cikin 1996, kamfanin tare da samar da ɓullo da thrombin kayayyakin tare da Cibiyar Nazarin Halittu Products da Drugs na Jinan Soja Command (Yuwei Drug Approval No. 118004, Patent CN1141951A).